Klein Lab
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Klein Lab

University of Colorado School of Medicine
Department of Dermatology
Department of Biochemistry & Molecular Genetics
UCHealth Dermatology Clinic

The Klein Lab at the University of Colorado Anschutz Medical Campus focuses on understanding the genetic determinants of skin cancer. We study these diseases through two complementary approaches: translational research using patient-derived models, and the development of novel genomic technologies to interrogate cellular behavior. Through this integrated approach, we aim to advance discovery, improve prognosis, and enhance diagnostics in clinical dermatology.

RESEARCH HIGHLIGHTS

Translational Research

Using patient-derived samples, organotypic skin models, and genomic profiling, we investigate the molecular drivers and tumor heterogeneity of cutaneous sarcomas and other rare skin tumors, with the goal of improving diagnostics and patient care.

Technology Development

We develop high-throughput perturbation-based genomic assays to systematically interrogate gene function and regulatory mechanisms, enabling scalable analysis of cellular behavior in health and disease.

Biobank & Patient-Derived Resources

Our lab maintains a curated biobank of rare skin cancer specimens and patient-derived resources that enable integrated genomic, single-cell, and functional studies of disease biology.